Endocrine Abstracts

Background: Postpartum depression (PPD) is a common mental health disorder with a major impact on maternal health and wellbeing and offspring development. Thyroperoxidase antibody (TPOAb) positivity is a major risk factor for postpartum thyroiditis and via this link, it is hypothesized that TPOAb positivity is a risk factor for PPD. However, the results of currently available single center studies are heterogeneous and affected by major study limitations.<p class="abstext"...

Objective: Defining thyroid function test abnormalities in pregnancy is complicated by changes in maternal physiology. Ideally, reference intervals (RIs) should be population-based and pregnancy-specific. Large methodological differences between published reports limit the adoption of such RIs into clinical practice.Methods: The study was performed in the Consortium on Thyroid and Pregnancy. In line with current consensus and the 2017 American Thyroid As...

Background: Postpartum depression (PPD) is a common mental health disorder with a major impact on maternal health and wellbeing and offspring development. Thyroperoxidase antibody (TPOAb) positivity is a major risk factor for postpartum thyroiditis and via this link, it is hypothesized that TPOAb positivity is a risk factor for PPD. However, the results of currently available single center studies are heterogeneous and affected by major study limitations.<p class="abstext"...

Objective: Gestational thyroid dysfunction and gestational diabetes mellitus (GDM) are common complications during pregnancy and often co-occur. Since thyroid hormones increase glucose uptake and insulin sensitivity, it has been hypothesized that hypothyroidism might increase the risk of GDM. Our aim was to study if maternal thyroid function test abnormalities are risk factors for GDM.Methods: A systematic search of Ovid MEDLINE, EMBASE and Web of Scienc...

Objective: Thyroid peroxidase antibody (TPOAb) positivity is the most important risk factor for overt/subclinical hypothyroidism and partly guides levothyroxine treatment indications during pregnancy. TPOAb positivity is usually defined by manufacturer cutoffs which are typically derived in non-pregnant populations with concentrations ≥95th percentile. Besides the general lack of assay uniformity, current TPOAb positivity cutoffs are likely to underestimate gestational t...

Objective: Adequate thyroid hormone availability is essential for foetal neurodevelopment. While overt maternal hypothyroidism is associated with lower offspring IQ, recent studies suggested an inverse U-shaped association, with suboptimal offspring neurodevelopment for both the lower and higher thyroid function range. Our aim is to investigate the association of gestational thyroid function with offspring IQ scores, assess if this association is different based on the gestati...